Evaluation and in Vivo Anti-Cancer Property of Methanol Extract of Acrostichum Aureum L and Insilco Toxicity Prediction

Abstract

This study is to evaluate the in vivo anti-cancer property of methanol extract of Acrostichum aureum L. against Dalton’s Lymphoma Ascites (DLA) murine models. Is done by Preparation of methanol extract of Acrostichum aureum L. leaves using cold extraction method and it is Determined by in vivo anti-tumour activity of methanol extract of Acrostichum aureum (MEAA) by administering MEAA in DLA-induced ascites-bearing animals, to know the progression of the tumour the Evaluation of tumour progression in MEAA treated ascites tumour-bearing animals is carried out and  haematological parameters of MEAA treated ascites tumour-bearing animals shows maximum effectiveness , Finally evaluation is done by MEAA treated tumour bearing animals. Analgesic and antioxidant activity of extracts from this species. Ethanolic extracts of A. aureum showed anti-fertility activity in rats as per the report of Dhar et al., in 1992. The cytotoxic effect of water and methanol extracts from a Bangladeshi specimen of A.aureum on gastric, colon and breast cancer cells were studied by Uddin et al., 2010. The anti-inflammatory activity of ethanolic (95%) crude extract of the roots of A. aureum was reported in varied carrageenan-induced inflammation rat models by Hossain et al., in 2011. Ethanol extract of A. aureum possesses analgesic activity and in vitro antioxidant activity which was found to be significantly effective in scavenging DPPH (EC50 =41.95μg/ml).