Design, Formulation and Evaluation of Drug Loaded Nanoparticles of Naproxen by Using Eudragit Rs-100

Abstract

In this research work we formulated biodegradable polymethyl metha crylate and eudragit RS-100 nanoparticles (NPs) containing Naproxen by nano-precipitation solvent displacement method to achieve a better free release profile for intra articular injection with improved efficacy. Dissolution study was revealed that increase the release of Naproxen from NPs. The particle size and size distribution of the Naproxen loaded PMMA and Eudragit Rs 100 nanoparticles were characterized by using a Zetasizer. The in vitro drug release indicated that the formulation NA2, NA4, NA5 And NA7 were not suitable for anti-inflammatory agent of drug as maximum amount of drug was released in the physiological environment of stomach and small intestine within 5 hours. Whereas, NA1, NA3 and NA6 formulations have released small amount of drug within 5 hours and 81.16%, 78.12% and 82.54% of drug was targeted to anti-inflammatory region from NA1,NA3and NA7. The results indicated that the prepared formulation was intact upto 12hrs. and transit was clearly seen. Drug release mechanism followed Non-Fickian transport.