A Comparative Study of the Effect of Dexmedetomidine, Clonidine and Magnesium Sulphate on Attenuation of Haemodynamic Response During Intraoperative Period and on Post- Operative Analgesia in Patients Posted for Abdominal Laparoscopic Surgeries Under Gene

Abstract

Background and Aim: In this study, effectiveness of Dexmedetomidine, Clonidine and Magnesium Sulfate in attenuation of haemodynamic response to laryngoscopy and intubation in patients posted for laparoscopic abdominal surgeries under general anaesthesia was compared and their intraoperative haemodynamic response was studied along with the requirement for postoperative rescue analgesia.

AIMS AND OBJECTIVES: To compare the effect of Dexmedetomidine, Clonidine and Magnesium Sulfate on attenuation of haemodynamic response during intraoperative period and on postoperative analgesia in patients posted for abdominal laparoscopic surgeries under general anaesthesia and the requirement of rescue analgesia.

Materials and Methodology: After institutional ethical committee approval, this double-blinded randomized study consists of 105 patients divided into 3 groups who are ASA I and ASA II, aged between 18-60 years, who underwent abdominal laparoscopic surgeries lasting not more than 3 hours. Group A: Dexmedetomidine (1 mcg/kg) Group B: Clonidine (1 mcg/kg) Group C: Magnesium Sulfate(40mg/kg). Haemodynamic parameters were recorded and analysed.

Results: Fall in heart rate (H.R.) was more with Dexmedetomidine than with clonidine and Magnesium Sulfate. Fall in blood pressure (B.P.) was more significant with Clonidine. Post-operative analgesic requirement was least with Dexmedetomidine group than with Magnesium Sulfate group and most with Clonidine group.

Conclusion: All 3 groups provided adequate haemodynamic stability but Dexmedetomidine was found to be better in providing controlled haemodynamic response as well as for control of postoperative pain.