Synthesis, Characterization and Evaluation of Quercetin Derivatives for Anti-Microbial and Anti-Fungal Activity

Abstract

The study involves synthesis, characterization and evaluation of anti-microbial and anti-fungal activity for the derivatives of quercetin. The product to be synthesized was selected on the basis of SWISS ADME predictor. The characterization of drug and their synthesised products was done by determination of melting point, UV spectroscopy, FTIR spectroscopy, thin layer chromatography, Nuclear Magnetic Resonance study. The anti-microbial and anti-fungal studies were done with different concentrations of 12.5 mg/ml, 25mg/ml, and 50 mg/ml with derivative 1 and derivative 2 using Pseudomonas aeruginosa Aspergillus Niger strains. The drug with 50mg/kg shows potent anti-microbial and anti-fungal activity with effective inhibitory growth parameter.