Role of Selenium and Metformin in Attenuating Lead Acetate Induced Renal Damage in Male Wistar Rats

Abstract

Nephrotoxicity is one form of toxicity which damages kidney due to the toxic or harmful agents or substances is called as nephrotoxicity. Pollutants that lead to renal toxicity are termed as nephron toxicants. Renal toxicity is a condition in which kidney fails to perform its proper function. Lead Acetate is used to induced nephrotoxicity or renal failure on male Wistar rats. It makes easy to study the therapeutics effects on nephrotoxicity. This study shows how Selenium and Metformin are effective in treating kidney damage in combination. Selenium is a kind of trace mineral element. It has antioxidant property which help in reducing oxidative stress level. Selenium also used to treat kidney failure by reducing MDA (Malondialdehyde). It is utilized to treat nephrotoxicity because of its medicinal properties.

Metformin drug which is used as oral antihyperglycemic agent which help in reducing level of blood glucose in a diabetic person. Metformin also has some properties which is used to treat nephrotoxicity. It has properties like anti-inflammatory, antioxidant, and have reno protective effect. By reducing oxidative stress metformin is used to diagnose renal or nephrotoxicity. Metformin helps in improving function of mitochondrial and modulating pathways of inflammatory. In combination Metformin and Selenium give effective result in treating renal damage or nephrotoxicity. Histopathological examination of kidneys of different groups have also shows the effective result.