“Correlation of Apolipoprotein A1 and Apolipoprotein B100 with Systolic Blood Pressure in Essential Hypertensive Subjects.’’

Abstract

Aim of the study- To investigate the correlation of apolipoprotein A1, apolipoprotein B, and their ratio in essential hypertensive subjects.

Material and Methods- This study was conducted in the Department of General Medicine of  J. A. Group of Hospitals associated with Gajara Raja Medical College, Gwalior, Madhya Pradesh. We have selected 100 patients of essential hypertensive subjects and 100 healthy normal individuals as controls. We analyzed lipid profile, apolipoprotein A1, and apolipoprotein B with the help of  BA 400 fully automated analyzer. 

Results- We found TC, TG, LDL-C, and VLDL-C were increased in essential hypertensive subjects except for HDL-C, which was found to be decreased. Apo A1 was found to be significantly decreased in essential hypertensive subjects compared to the controls. Apo B and the ratio of ApoB/A1 were significantly higher in the essential hypertensive group than in the control group. The mean values of Apo A1 in the essential hypertensive group and the control group were 145.10±12.10 and 149.12±13.08 respectively. Furthermore, Apo B in the essential hypertensive group and the control group were 115.96±14.67, and 87.52±11.41 respectively. Apo A1 was negatively correlated (r value -18) with SBP, while Apo B and ApoB/A1 were highly positively correlated with SBP with r values of +0.24 and +0.64, respectively.

Conclusion- We have concluded that Apolipoprotein A1 and Apolipoprotein B, along with their ratio Apo B/Apo A1, should be used to predict CVDs in essential hypertensive subjects.