Platelet Rich Fibrin (PRF), Future of Pulp Preservation: An Umbrella Review

Abstract

Introduction: Vital pulp therapy is to preserve and maintain pulp tissue that has been damaged but not completely destroyed by trauma, dental caries, or other iatrogenic causes. PRF is a second-generation platelet concentrate and an autologous healing biomaterial.

Population: - Databases were evaluated with adult patients with pulp exposure having either mature or immature roots, reversible pulpitis.

Intervention: - Data extraction and analysis of research papers based on Platelet Rich Fibrin (PRF).

Comparison: - MTA, Biodentine, calcium-based silicates, calcium hydroxide, glass ionomer, resin modified glass ionomer, blood clot, plasma rich platelet (PRP), Artificial scaffolds and other pulp capping agents.

Outcome: - PRF has regenerative properties, stimulate proliferation and differentiation of dental pulp cells, conducive to healing, dentin bridge formation.

Objective: The aim of the study was to study the effectiveness of platelet rich fibrin as direct pulp capping agent in young permanent teeth.

Methods: Electronic databases such as Scopus, Ebsco and PubMed were searched. In the search systematic review and meta- analysis, clinical studies and randomized clinical trials were included.

Results: Platelet Rich Fibrin (PRF) can be used as a direct pulp capping agent.

Conclusions: Platelet Rich Fibrin (PRF) can be a suitable biological and economical choice for pulp capping agent owing to its regenerative properties. It could be promising alternative for direct pulp capping procedures.