“A Comparative Study of Platelet Rich Plasma Dressing and Normal Saline Dressing in Ulcer Healing”

Abstract

Background: Wound healing is a dynamic process involving tissue repair. It is broadly considered to have significant tissue formation and remodelling. PRP is an autologous concentrate of human platelets and has granules which release the proteins, chemokines and cytokines required for the tissue repair process, mimicking and aiding in the ongoing process of wound healing at the ulcer site. Therefore, the present study was conducted to compare the efficacy of Platelet rich plasma dressing with Normal Saline  dressing in wound healing in cases of ulcer.

Method: A total of 62 patients having ulcers and meeting the inclusion and exclusion criteria were included after obtaining written informed voluntary consent from the patients. They were randomized into two Groups of 31 cases each: Group PRP and Group NS. Demographic details, details of past and personal histories along with ulcer sizes and durations were recorded. Findings of general and systemic examinations were noted. Routine laboratory investigations were done. The dressing was done as per the assigned Group, with either PRP or NS. Duration for complete healing was recorded and compared in both the groups.

Results: The two groups were similar in terms of demographic variables. The distribution of duration of ulcer and type of ulcer were similar in the two groups (P value: more than 0.05).

Conclusion: It may be effectively concluded that PRP dressing has faster and complete healing as compared to NS dressing.