Study of Tablet in Tablet Approach for the Designing and Evaluation of Antidiabetic Combined Immediate and Modified Release Tablets

Abstract

Oral administration is the most common method, when it comes to medication. Although there are certain medications that are meant to be dissolved in the mouth when they are taken orally, the overwhelming majority of medications that are taken orally are still swallowed. When compared to other methods of drug administration, the oral route of drug administration is the most common and has been used with great effectiveness for the delivery of drugs following traditional methods. Tablets are the most extensively used dosage form among all of the possible dosage forms. This is due to the fact that they are easy to administer, have a reduced manufacturing cost, and are elegant. Coating processes largely determine the visual qualities of a product, including its colour, texture, mouth feel, and ability to disguise flavour. There are several limitations or problems associated with this coating technique; nevertheless, one of the greatest options is the tablet in tablet, which works to overcome these limitations. For the purpose of conducting anti-diabetic research, the current work is to conduct a full assessment of the formulation, characterization, and obstacles involved in the production of tablets in tablet dosage form. The formulation is to create a tablet-in-tablet of gliclazide, metformin by developing a modified release core tablet of gliclazide SR and its outer shell, which will act as an immediate release tablet of metformin.