Exploring 2-(Furan-2-yl) Quinoline-4-Carboxylic Acid: Synthesis,Characterization, Biological and Electrochemical Analaysis

Abstract

Employing Isatin as the precursor and 2-acetylfuran within an alkaline medium, the present investigation sought to synthesize a lead-optimized heterocyclic compound, specifically 2-(furan-2-yl) quinoline-4- carboxylic acid. The structural confirmation of the synthesized derivatives was achieved through the application of Mass spectrometry, 13C-NMR, and 1H-NMR spectroscopy. The cyclic voltametric technique was employed to scrutinize the electrochemical characteristics of the aforementioned 2-(furan-2-yl)quinoline-4-carboxylic acid. A glassy carbon electrode facilitated the examination of the impacts of concentration variations and scan rates. The entire electrode process was governed by diffusion control mechanisms. A proposed mechanism for the electrode reaction was formulated.
The in vitro anti-tuberculosis activity was assessed utilizing the Microplate Alamar Blue assay methodology for the synthesized compounds, which exhibited good minimum inhibitory concentration (MIC) comparable to that of the standard antitubercular agents streptomycin, pyrazinamide, and ciprofloxacin; thus, the compound demonstrated promising activity relative to the established standards.