C - Reactive Protein as a Predictive Marker for Inflammatory and Cardiovascular Risk among Hemodialysis Patients.

Abstract

Background: C- reactive protein (CRP) has been shown to be both a marker and a mediator of atherosclerosis. Chronic inflammation is an important component in the development and progression of atherosclerosis.  Low serum albumin concentrations, elevated Blood urea nitrogen and Creatinine ratio, neutrophil-to-lymphocyte ratio (NLR) associated with inflammation and all-cause cardiovascular mortality.

Methods: This study includes total of 35 post Haemodialysis patients undergoing dialysis treatment. Haematological parameters, lipid profile, total protein, albumin, blood urea Creatinine ratio and Neutrophil lymphocyte ratio were assessed. All Statistical analysis in the study was performed using SPSS for window version 20.0.  The results summarized as mean ± Standard deviation (SD) and a P-value of less than 0.05 was considered to be statistically significant.

Results: The association in age group was significant (χ² =5.777, P < 0.05) in post HD patients. There were no significant correlation observed between CRP and lipid profile, protein parameters, endotoxin and haematological parameters among the study subjects.

Discussion: C-reactive protein CRP is a sensitive marker of inflammation in haemodialysis patients. A negative correlation was observed between the MCHC with the CRP status and also between the BUN and the HDL cholesterol levels. Inflammation associated with atherosclerosis decrease in HDL, increase in total cholesterol and LDL.

Conclusion: The association of CRP with HDL, LDL, endotoxin, UCR, NLC, haemoglobin and albumin is the predictive risk of inflammation in haemodialysis patients. Our study underscores the potential of CRP in improving risk stratification and personalized management strategies in haemodialysis patients.