A Prospective Randomized Comparative Study of the Intraoperative Hemodynamic Parameters and Adverse Effects of Single Preemptive Dose of Oral Pregabalin Versus Oral Gabapentin on Sub Arachnoid Block in Patients Undergoing Elective Infra Umbilical Surgerie

Abstract

Introduction: Preemptive analgesia is defined as an anti-nociceptive treatment that prevents the establishment of altered central processing of afferent input, which amplifies postoperative analgesia. Various drugs such as local anaesthetics, opiods, non-steroidal anti-inflammatory drug, cyclooxygenase-2 inhibitors, gabapentin, pregabalin, clonidine and dexmedetomidine have been used as preemptive analgesics.

Aims: This study aims to assess the intraoperative effects of single pre-emptive dose of oral Pregabalin versus oral Gabapentin on Sub arachnoid block in patients undergoing elective infra umbilical surgeries on hemodynamics (Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure and Heart Rate). In addition, the adverse effects like postoperative nausea, vomiting, sedation and dizziness were also assessed in the study.

Methodology: Ninety cases were included, on whom the routine monitoring of heart rate, blood pressure, peripheral oxygen saturation and ECG was instituted intra-operatively.

Results: There was no statistically significant difference with respect to the hemodynamic parameters or adverse side effects included in the study.

Conclusion: The findings of the study suggests that the preemptive oral Pregabalin and Gabapentin on Sub arachnoid block in patients undergoing elective infra umbilical surgeries provide a safe intraoperative and post-operative analgesia with maintained hemodynamic parameters and minimal adverse side effects.