Understanding the Diagnostic Value of Inflammatory Cytokines TNF-Α, IL-1β, and IL-6 in Alzheimer's Disease
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Abstract
Alzheimer's disease(AD) is a progressive brain disorder that slowly deteriorates memory, thinking, and reasoning abilities eventually damage the capacity to do simple tasks. Dementia is mainly caused by it. Dementia is a set of brain degenerative illnesses that affect memory, thinking, and daily duties. These disorders are defined by nerve cell breakdown and brain injuries. Dementia primarily affects older persons and is not a normal component of aging. The aim of the current study was to investigate the role of pro-inflammatory cytokines in the diagnosis of AD. 30 patients diagnosed with AD were recruited and compared with 10 healthy control, utilizing the Mini Mental State Examination score (MMSE). AD was evaluated and staged. Patients' cognitive scores were considerably lower than the control mean. Tumor Necrosis Factor α, interleukins -1β and interleukins -6, were measured in human serum using sandwich Enzyme Linked Immuno sorbent Assay (ELISA) technique. Serum levels of all three markers were measured, and the results showed that levels of the three biomarkers were higher in AD patients when compared with control group.