“Unveiling the Wound Healing and Hypoglycemic Effects of Garcinia cambogia (L.) Roxb. in Streptozotocin-Induced Diabetesin Albino Wister Rats”

Abstract

Garcinia cambogia (L.) Roxb(G. cambogia), known as Malabar tamarind, has garneredattentionfor its purported health benefits, particularly in weight loss and metabolism regulation. However, its potential in managing diabetes and wound healing remains underexplored. This study investigated varying doses of G. cambogiahydroethanol extract on parameters related to diabetes management, wound healing, and tissue integrity. Results showed significant variations in body weight among treatment groups, with Gliclazide treatment resulting in notable reductions. G. cambogia extract effectively reduced serum glucose and triglyceride levels in diabetic rats, indicating its potential for managing diabetes. Additionally, it positively impacted antioxidant activity and pancreatic islet morphology, suggesting benefits in mitigating oxidative stress and preserving pancreatic β-cell architecture. Moreover, oral administration of G. cambogia extract accelerated wound healing by reducing wound contraction and epithelialization time, while also enhancing wound breaking strength. Scratch assay results demonstrated its potential in enhancing cell migration and wound closure. However, the highest dose showed a potential plateau or decline in efficacy, highlightingthe importance of dosage optimization in wound healing interventions. Overall, the findings underscore the therapeutic potential of G. cambogia in promoting wound healing, tissue integrity, and diabetes management, with implications for developing effective treatment strategies fordiabetic complications.