Exploring Preformulation Characteristics and UV Method Development of Clobetasol Propionate for Enhanced Formulation Design

Abstract

In order to enhance formulation design, the current work aimed to perform preformulation studies and developed a UV technique for clobetasol propionate analysis. Clobetasol propionate is a corticosteroid that is used to treat a number of inflammatory skin conditions. A thorough preformulation profiling was performed to evaluate the drug's physicochemical properties, such as solubility, partition coefficient, pH-solubility profile, and stability. The findings provided useful insights into the drug's behaviour and aided in the selection of appropriate formulation options.

Additionally, a UV spectrophotometric method for quantifying clobetasol propionate was devised. The method's wavelength selection, linearity, accuracy, precision, were all optimized. In terms of roubestness, LOD, LOQ and repeatability, the validated UV technique produced satisfactory results.

The combination of preformulation profiling and UV method development gave a thorough grasp of the drug's properties as well as a dependable analytical instrument for its measurement. The gathered data can be used to build clobetasol propionate formulations, allowing for the development of optimised pharmaceutical products with improved efficacy and stability.