Phytochemical Study and Potential of Antibacterial Performance of Dittrichia Viscosa Subsp. Viscosa

Abstract

Dittrichia viscosa (D. viscosa) is a native distributed species around Albayda City, northeast of Libya. Although it has been previously studied, but with the different ecosystems in the study region, this study is the first. Therefore, this study aimed to determine the phytochemical composition and antibacterial effects of methanol extracts of root, stem, and leaf extracts of D.viscosa native to Albayda City, Libya. Methanol, Soxhlet, and rotary evaporator were used for solubility, extraction, and evaporation. The agar well and agar disc diffusion methods were used to evaluate the antibacterial activities of extracts and antibiotic references, respectively. The results showed broad antibacterial activities against MDR bacteria with inhibition zones ranging from (15.5+0.2 to 29±0.2), the highest was 29mm from the leaf and 27.5±0.1 from root extracts against P. aeruginosa followed by 24±0.1 from root extract against Acinetobacter baumannii. The investigation of phytochemicals proved that the plant consists of the most common bioactive compounds previously confirmed for their antibacterial potential. Ethyl.alpha.-d-glucopyranoside (14.88%), 1-Deoxy-d-mannitol (14.45%), Quinic acid (13.4%), beta.-D-glucopyranoside, methyl (12.95%), 9,12-Octadecadienoic acid (Z,Z)- (4.67%), Neotigogenin (4.58%), and gamma – Sitosterol (2.73%) were the highest major compound. This study concludes that Dittrichia viscosa plant could be considered a natural source of compounds that help for promoting patients health by fighting harmful bacterial pathogens such as Methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, and Acinetobacter baummannii.