An Overview of Potential Nanotechnological Methods for Psoriasis Treatment

Abstract

Introduction: Psoriasis is a chronic, immune-mediated skin disorder characterized by hyperproliferation of keratinocytes, inflammation, and the formation of red, scaly plaques. Conventional therapies, including topical treatments, phototherapy, and systemic drugs, often have limitations such as side effects, low skin permeability, and reduced patient compliance. Nanotechnology offers a promising approach to overcome these challenges by enabling targeted drug delivery, enhanced therapeutic efficacy, and reduced systemic toxicity. This review explores the potential of nanotechnological methods for the effective treatment of psoriasis.
Objectives: The objective of this study is to provide an overview of emerging nanotechnological strategies for psoriasis treatment, focusing on their mechanisms, efficacy, and potential to address current therapeutic limitations.

Methods: A comprehensive literature review was conducted, analyzing studies on various nanocarriers such as liposomes, niosomes, solid lipid nanoparticles, dendrimers, and polymeric nanoparticles for the delivery of antipsoriatic drugs. Key parameters, including drug encapsulation efficiency, skin penetration, and therapeutic outcomes, were evaluated to assess the effectiveness of these nanotechnological methods.

Results: Nanocarriers demonstrated enhanced drug stability, controlled release profiles, and improved skin penetration compared to conventional formulations. Liposomes and niosomes facilitated the localized delivery of drugs with minimal systemic absorption, reducing side effects. Solid lipid nanoparticles and polymeric nanoparticles showed significant improvement in anti-inflammatory and antiproliferative effects in preclinical models of psoriasis.

Conclusions: Nanotechnology-based approaches hold immense potential for revolutionizing psoriasis treatment by addressing limitations of conventional therapies. Further clinical studies are needed to establish their safety, efficacy, and scalability for routine clinical applications.