Evaluation of the Anti-Parkinson Activity of Curly Kale (Brassica Oleracea) In Albino Swiss Mice.

Abstract

Plant extract that was submitted to phytochemical analysis revealed the existence of many bioactive compounds including proteins, carbohydrates, saponins, flavonoids, alkaloids, phenols, tannins, and terpenoids, but lacking glycosides. Given its many qualities, the plant could have medicinal and medical applications. The effects of bromocriptine and the plant extract (KEE) on motor coordination, locomotor activity, catalepsy, dopamine concentration, and oxidative stress were evaluated in a Parkinsonian model generated by haloperidol. Using the Rotarod test, KEE (100–500 mg/kg) and bromocriptine (5 mg/kg) were shown to improve motor coordination; the effects of KEE were more noticeable at higher doses. KEE improved in a dose-dependent manner, according to the Actophotometer assessment, and both bromocriptine and KEE reduced the locomotor activity that had been reduced by haloperidol. Larger doses of KEE, particularly the 500 mg/kg dose, also shown favourable benefits. Bromocriptine dramatically reduced catalepsy scores in the catalepsy test. Bromocriptine and KEE both significantly raised dopamine levels; UV spectrophotometry demonstrated a dose-dependent increase in dopamine. Larger doses provided even more significant protection against the oxidative stress generated by haloperidol. Additionally, KEE increased brain catalase activity. Overall, the results show that both bromocriptine and KEE may have neuroprotective benefits, with KEE showing promise as a therapeutic benefit on a number of fronts.