Comparison of Haemodynamics and Recovery Characteristics of Sevoflurane versus Desflurane in Adult Patients Undergoing Elective Surgeries under General Endotracheal Anaesthesia

Abstract

 Introduction: Management of haemodynamic stability and early recovery is the most important part of a standard balanced anaesthesia technique. The aim of this study is to prospectively compare the haemodynamics and recovery characteristics of sevoflurane with that of desflurane in general anaesthesia

Methods: Sixty ASA (American Society of Anaesthesiologists) physical status class I and II patients aged between 18-60 years admitted as inpatients, undergoing elective surgeries lasting for less than two hours under general anaesthesia were randomly assigned to receive Desflurane or Sevoflurane as maintenance agents. Anaesthesia was induced with Inj. propofol 2 mg/kg IV, and maintained with either desflurane 3%-6% (n = 30) or sevoflurane l%-2% (n = 30) with 50% nitrous oxide in oxygen. Intraoperative analgesia and neuromuscular block was achieved using fentanyl 1mcg/kg and vecuronium, respectively. The inhalational anaesthetics were titrated to achieve an adequate clinical depth of anaesthesia and to maintain mean arterial pressure (MAP) within 20% of the preinduction baseline values. Heart rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and Mean arterial pressure (MAP) were recorded preoperatively, at induction and then at regular intervals. After extubation, early recovery was recorded by time to verbalise and orientation to time and place. In post-anaesthesia care unit, intermediate recovery was assessed by modified Aldrete Score.

Results: The intraoperative haemodynamic characteristics were comparable with both sevoflurane and desflurane. The early and intermediate recovery time was shorter after maintenance of anaesthesia with desflurane compared with sevoflurane.