Synthesis, Biological Evaluation, And Kinetic Studies of Novel 3-Methoxynaphthalen-1-Amine Derivatives

Abstract

The novel series of 3-methoxynaphthalen-1-amine derivatives has been synthesised. Skraup reaction method was used to synthesise the 6-methoxy-8-nitroquinoline. Further reduction and aldehyde substitutions, 10 novel compounds were synthesised. All the final compound structures were confirmed by the NMR and LCMS analysis. In the antibacterial studies, the compound (3a – 3j) was found to possess a good ZOI value than standard drugs against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Klebshella pneumonia respectively. The kinetic results of the enzyme by the Lineweaver-Burk plot of compound 3j showed that Vmax remains the same without significantly affecting the slopes. These compounds could be further modified to develop potential and safer antibacterial agents.