Evaluation of Repaglinide Loaded Floating Microspheres Prepared from Different Viscosity Grades of Hpmc Polymer

Abstract

Repaglinide-encapsulated floating microspheres were developed and characterized during the investigation to extend the drug's residence period in stomach and subsequently boost its bioavailability. By using the emulsion solvent diffusion technique, floating microspheres of hydroxypropyl methyl cellulose (HPMC) and ethylcellulose (EC) (5 and 100 cps) were created. Numerous parameters, including the drug:polymer ratio, polymer ratio, emulsifier concentration, and stirring speed, were examined during process optimization. A few chosen optimal formulations were examined for drug release, kinetics, entrapment, and flying behavior. The microspheres ranged in size from 181.1 to 248 lm. For twelve hours, good buoyancy and entrapment were noted. The optimized formulation stayed buoyant for over six hours, as evidenced by the X-ray image. When compared to the pure medication treated group, the optimized formulation treated group exhibits a significant (p < 0.01) decrease in blood glucose levels. Repaglinide- loaded floating microspheres are anticipated to provide a new option for an affordable, safe, and more bioavailable formulation for NIDDM therapy.Abstract: Repaglinide-encapsulated foaming microspheres were developed and evaluated during the investigation to extend the drug's residence duration in gel and, consequently, boost its bioavailability. By using the emulsion solvent diffusion technique, floating microspheres of hydroxypropyl methyl cellulose (HPMC) and ethylcellulose (EC) (5 and 100 cps) were created. Many parameters were examined during process optimization, including the drug:polymer ratio, polymer ratio, concentration of emulsifier and stirring speed.