Development and Validation of Simultaneous Estimation of Enalapril and Irbesartan by Spectroscopic Method

Abstract

This research aimed to create and verify a new spectroscopic technique for the simultaneous measurement of two commonly used antihypertensive medications, enalapril and irbesartan. The method, which offered a straight forward and affordable substitute for the routine study of pharmaceutical formulations comprising both chemicals, was based on the concepts of UV-visible spectrophotometry. The ICH requirements were followed in the validation process of the created technique, taking into account parameters including linearity, precision, accuracy, specificity, and robustness. For both enalapril and irbesartan, the method demonstrated excellent linearity over a broad concentration range, with correlation values above 0.99. Recovery experiments were used to evaluate accuracy, and the findings were adequate within reasonable bounds. The developed spectroscopic method offers several advantages, including simplicity, rapidity, and cost-effectiveness, making it suitable for routine analysis in pharmaceutical quality control laboratories. This technique aids in effective drug analysis and formulation monitoring by permitting the simultaneous estimation of enalapril and irbesartan, possibly improving patient safety and therapeutic results.

DOI: https://doi.org/10.52783/jchr.v14.i5.6142