Comparative Effects of Fentanyl and Clonidine with Chloroprocaine, Respectively, in Lower Limb and Abdominal Surgery

Abstract

Research findings have indicated that CP exhibits a more rapid recovery from anesthesia in comparison to 0.5% Bupivacaine. Furthermore, previous research has determined that the neuraxial administration of CL effectively suppresses the release of spinal substance P. Additionally, research findings have indicated that F exhibits a significantly lower affinity for kappa receptors situated in the spinal cord. Therefore, the objective of our study was to evaluate and compare the effects of CP in combination with F and CP in conjunction with CL.Sixty patients were split evenly. Both Group C and Group F were given CP in addition to CL and NS, respectively. In addition to this ,(T, PR, BP, RR,CNS, CVS, lungs, and airways, etc.), a full hemogram (including PT, BT, CT, BSL, CU, SE, X-ray of the chest in the PA view, and ECG) was performed. No medications were given to any patients prior to the start of the anesthetic procedure. All patients were briefed on the SA-B technique.In our study, we found that on comparing PR at STI, statistically significant variation was observed at 30min, 45min, 60min, 75min,75min& 90min, as the p values were 0.047, 0.018, 0.002, 0.001, and 0.011, respectively, and on comparing MAP at STI, significant variation was observed at 0min, 5min, and 10min, as the p value was 0.000.It has been observed that low-dose (1%) CP in conjunction with either F or CL as an adjuvant is beneficial in procedures with a duration of less than 90 minutes.