Revitalizing Endo-Perio Lesions: Harnessing the Power of Concentrated Growth Factor

Abstract

Endodontic-periodontal lesions (EPLs) pose a significant clinical challenge due to their complex interplay between pulp and periodontal tissues. These lesions arise from various etiological factors, including caries, trauma, and restorative procedures, triggering distinct pathogenic processes. Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) have shown promise in treating EPLs, albeit with drawbacks such as the need for anticoagulants and a time-consuming preparation process. Concentrated growth factor (CGF), a newer second-generation platelet concentrate, offers a natural and efficient alternative. This manuscript presents a case report of a 21-year-old female patient with an endo-perio lesion on tooth 11, managed using CGF in conjunction with demineralized freeze-dried bone allograft (DFDBA) and open flap debridement. The patient's treatment journey, from diagnosis to surgical procedure and post-operative care, is meticulously described. The preparation of CGF and its application in the regenerative procedure are outlined, highlighting its superior biological properties and potential for tissue regeneration. The manuscript underscores the efficacy of regenerative approaches in addressing EPLs and emphasizes the promising role of CGF in achieving successful clinical outcomes. Furthermore, the long-term success rates of regenerated teeth reported in existing studies provide substantial support for the durability and efficacy of regenerative therapies in periodontal treatment. In conclusion, using CGF alongside DFDBA and open flap debridement represents a sophisticated and evidence-based approach to addressing intrabony defects in periodontitis patients, offering hope for lasting periodontal health and regeneration.