Design and Characterization of Effect of Penetration Enhancer of Transdermal Patch of Antipsychotic Drug

Abstract

Schizoaffective disorder is a combination of schizophrenia and a mood disorder. Both disorders could be diagnosed separately and are present in full in the same patient. Critically, the psychosis must be present for at least 2 weeks when the mood disorder is not present. Additionally, the mood disorder must be diagnostically present during a majority of the active and residual phases of the illness. Olanzapine transdermal patch combines a slow release formulation of a chronic treatment of schizophrenia in patients. The proposed model drug olanzapine was initially used orally and intramuscularly for the chronic treatment of schizophrenia in patients. The aim of this work was to study the permeation of olanzapine across the skin. The proposed formulations have a number of variables i.e. plasticizers, penetration enhancers, rate controlling process and adhesion on skin. Simple drug-matrix type of transdermal drug delivery system for both type of drugs were designed for prolonged period of maintenance therapy instead of convention oral dosage forms. Moreover, the physicochemical characteristics of olanzapine also comply  with  the  general  requirement  for designing a TDDS to a good extent. We may be improving the therapeutic effect of drugs via approaches as transdermal patch hold on to part of skin. The power of adhesion of patch creates good penetration ability of TDDs by using arrangement of different penetration enhancers.