Formulation And Evaluation of Immediate Release Tablets Of Valsartan

Abstract

The main objective was formulation and evaluation of immediate release tablets of valsartan. In the present study, valsartan 200 mg immediate release tablets were prepared by direct compression, considering amount of Croscarmellose sodium, Crospovidone and Sodium stearate as three independent variables and in vitro drug dissolution studies were performed to find out the drug release rate and patterns. In- vitro drug release was carried out using USP Type II dissolution test apparatus 37 °C ± 5 °C and 50 rpm in 750 ml of 0.1 N Hydrochloric acid for 2 hours and then the pH was charged to 6.8 by adding 250 ml of 0.2 M tri sodium orthophosphate for the rest of  the dissolution duration. 5 ml of sample was withdrawn at predetermined time intervals replacing with an equal quantity of drug free dissolution fluid, then drug release percentage was estimated by spectrophotometer at 249nm. The all prepared formulas were tested for bulk density, tap density, angle of repose, hausner’s ratio, thickness, weight variation, hardness, friability, drug content, in vitro dissolution test, floating time. Drug excipients compatibility was checked with the help of Fourier Transform Infrared Spectroscopy (FTIR). The drug content of all the formulations ranged from 98.5±0.1% to 98.4±0.7%. The formulation (F1) with Croscarmellose sodium was found to be best formulation with In-vitro drug release of about 99.5% at the end of 30 minutes. It can be concluded that the selected formula (F6) can be a promising  formula for the preparation of immediate  release of valsartan.