Exploring the Therapeutic Potential of Aqueous Psidium Guajava Extract: Anti-Anaphylactic and Anti-Asthmatic Efficacy in Experimental Models

Abstract

The medicinal plant Psidium guajava L, which is known for its high content of tannins, triterpenes, flavonoids, quercetin, pentacyclic triterpenoid, and ursolic acid, demonstrates a variety of pharmacological effects, including antioxidant, anti-inflammatory, anti-cough, anti-diabetic, and antimicrobial properties. Animals were used to assess the anti-anaphylactic and anti-asthmatic capabilities of the aqueous extract of Psidium guajava (Myrtaceae). Psidium guajava extracts were orally fed to rats at 125, 250, and 350 mg/kg bw for 14 days. Modulation of experimentally produced airway inflammation, oxidative stress, TNF- levels, and lung histopathology were evaluated. Using a milk-induced eosinophilia and leukocyte count model, the anti-asthmatic action was further examined. The reduction of eosinophils and leukocytes indicated the efficiency of Psidium guajava in preventing anaphylaxis and asthma. These findings reveal the therapeutic potential of Psidium guajava as a helpful natural cure for illnesses linked with airway inflammation and immunological responses, promoting additional research into its applications in the treatment of anaphylactic reactions and asthma