Development and Therapeutic Assessment of Solanesol-Loaded Transdermal Patches for Its Wound Healing Potential

Abstract

This manuscript comprehensively evaluates the performance of nine transdermal patch formulations (F1-F9) containing solanesol. Through a series of tests and analyses, including gel fraction, swelling index, water vapor transmission rate, mechanical properties, surface morphology, moisture retention, thickness and weight variation, folding endurance, residual solvent analysis, pH determination, drug content uniformity, and adhesive properties, we provide a detailed understanding of each formulation's physical, mechanical, and chemical characteristics. Additionally, safety assessments, permeation studies, stability testing, in vitro release studies, drug release kinetics, histopathological studies, in vivo efficacy studies, and in vitro-in vivo correlation studies are conducted to evaluate the patches' therapeutic potential and reliability. Results highlight formulation F6 as a standout candidate, demonstrating superior gel fraction, swelling index, moisture retention, mechanical properties, adhesive characteristics, and safety profile. Furthermore, F6 exhibits excellent stability, controlled drug release, and promising wound healing properties, making it a compelling choice for transdermal drug delivery applications.