Antiparkinson’s Activity of Curcumin Extract Loaded Phytosomal Intranasal Gel

Abstract

Purpose

Curcumin is a Phytoconstituents obtained from Curcuma longa rhizome. Curcumin is having anti-inflammatory and anti-oxidant properties. The extract would show antiparkinson’s activity Oral use of this drug has some limitations like less solubility, Low bioavailability, High first pass Metabolism. The aim of the present investigation was to formulate Curcumin extract loaded Phytosomal gel for improved delivery and to target brain

Method

Phytosomal formulations were prepared using different methods like solvent evaporation method, salting out anti solvent precipitation method, direct egg yolk method and egg lipid method. Phytosome were characterized by using Scanning Electron Microscopy, Particle size, FTIR, XRD etc. Optimized batch was further transferred into gel formulation and further evaluated for various physical parameters. The final batch was subjected for different animal study Antiparkinson’s activity,

Result

Phytosome were characterized by using Scanning Electron Microscopy, Particle size, FTIR, XRD etc. salting out Phytosome prepared by anti-solvent precipitation method showed best results. Further Full Factorial Design: A 3² randomized full factorial design was used in this study. In that batch F5 showed 56±1.029 % CDR, and entrapment efficiency of 81±1.53%. Depending upon variable concentration of Cholesterol and Phosphatidylcholine. Different batches of Phytosomal gel formulation were prepared using Carbopol as gelling base and further evaluated. Out of three batches F5G1, F5G2 and F5G3 the batch F5G2 showed better result for Spreadability (24.30 ± 0.25), Viscosity (5421cps at 100rpm) Drug Content (67.63 ±1.07%), and Extrudability (78.84±0.52) as compared with other batches. In-vitro drug diffusion study showed that diffusion of drug was enhanced across the membrane due to having Phytosomal formulation. Curcuma longa Phytosome gel (Batch F5G2) was found to follow Higuchi’s kinetic. Antiparkinsonian activity of test nasal gel formulation showed improvement in behavioral pattern.

Conclusion:

The phytosomal gel formulation administered through nasal route would be best choice for better treatment of Parkinson’s disease.