Harnessing the Therapeutical Value of Andrographis Paniculata

Abstract

The plant Andrographis paniculata, sometimes referred to as the "King of Bitters," has long been valued for its wide range of pharmacological qualities in conventional medical systems. This review sheds insight on the various pharmacological activities of Andrographis paniculata through a scientific exploration. The bioactive components of the herb, including diterpenoids, neoandrographolide, and andrographolide, have strong immunomodulatory effects by boosting the generation of cytokines and immune cells. Additionally, the plant extract exhibits strong anti-inflammatory qualities by blocking pro-inflammatory mediators including NF-κB and COX-2, potentially providing therapeutic alternatives for inflammatory ailments. This review article shades the mechanism involved in various pharmacological activities of the plant with special reference to its toxicity concern. Special attention was given to the clinical investigation being conducted for their pharmacological applications.