Comparative Dissolution Profile Study Of Aciclovir In Solid Dosage Formulations

Abstract

This study compares the in vitro efficacy of two distinct brands of acyclovir tablets with the same strength—ACYPROVE-200 (Aciclovir  Tablet IP) and ZOVIRAX TABLETS (Aciclovir Tablet IP200MG).Friability, hardness, thickness, solubility, and weight fluctuation tests are only a few of the many comparisons. The most crucial test that enables us to ascertain the precise concentration of the active ingredient (acyclovir) in every capsule and the quantity of medication discharged from these formulations is the dissolution test.Because of its great solubility and limited permeability, the medication aciclovir is categorized as Class III in the BCS classification.Dissolution tests were conducted in acid medium, pH 4.5 buffer medium, and pH 6.8 buffer medium in this study. The dissolution rate is determined by measuring the amount of medication released at intervals of 10, 15, and 30 minutes. The results also show the similarity and difference between the two products.The study concludes that there is a range of 0–15 and 50–100 for the Difference factor (f1) and Similarity factor (f2) between "ACYPROVE-200 (Aciclovir Tablet IP) and ZOVIRAX TABLETS (Aciclovir Tablet IP200MG)."