Development and Evaluation of Pulsatile Drug Delivery System for Management of Hypertension

Abstract

The objective of this work was to develop the pulsatile drug delivery system of Ramipril i.e antihypertensive drug to enhance the patient compliance. The pulsincap system gives the desired lag time to release and carry the two different types of dosage form i.e immediate release granules and sustained release microparticles. An immediate release granules provides the immediate release of drug in 30 minutes after the lag time to achieve therapeutic concentration in the body, while sustained release microparticles provide sustain release of drug to maintain the therapeutic concentration of the drug for prolonged time. In this study physicochemical property of ramipril was improved by using solid dispersion technique. Solid dispersion of ramipril was prepared with PEG 6000 polymer at three drug: polymer ratios (1:1), (1:2) and (1:3). The solid dispersion (1:3) showed maximum solubility. Immediate release granules were prepared using wet granulation method. Cross carmellose sodium was used as super disintegrating agent. Sustained release microparticles were prepared by solvent evaporation technique. Ethyl cellulose was used as the polymer in different ratios with drug. The specific 6 hours lag time was achieved by treating gelatin capsules with formalin vapours. . So, it can be concluded that pulsincap system of Ramipril control the risk of high blood pressure and heart attack, by giving immediate release within 30 minutes and maintain the drug level for 12 hours.