Establishing a Connection between Vitamin D and Telomerase-Measured Cellular Senescence in Pre-HTN: An Observational Study

Abstract

Aim: The aim of the present study was to explore the link between Vitamin D and cellular senescence measured with the enzyme telomerase in pre-HTN.

Methods: The current observational research was carried out by the Physiology Department in association with Pathology. Participants were required to be of either sex and have a systolic blood pressure (SBP) of 120-139 mm Hg and a diastolic blood pressure (DBP) of 80–89 mm Hg in order to be included in the pre-hypertensive group (n = 75). People in the control group (n = 75) were all healthy adults (i.e., 18-25 years old) whose systolic blood pressure (SBP) was 100–119 mm Hg and diastolic blood pressure (DBP) was 60-79 mm Hg. 

Results: About 150 healthy people were studied. 75 patients were pre-hypertensive, aged 22.58±1.56, whereas controls were 18.82±1.24. Out of 150, 45 males, 30 females were pre-HTN and 40 men, 35 females were control. Height and waist-hip ratio did not vary significantly across groups. Compared to controls, pre-HTN group subjects had higher BMI (P < 0.001) and weight (P < 0.001). The pre-HTN group had substantially higher HR, SBP, DBP, MAP, and RPP compared to controls (P < 0.001). PP was somewhat higher in pre-HTN group and adversely linked with Vitamin D. Waist-hip ratio, SBP, DBP, MAP, and RPP are correlated with high telomerase levels, whereas BMI, HR, and PP are not.

Conclusion: Reduced Vitamin D levels in pre-HTN may disrupt cardiovascular homeostatic mechanism and accelerate telomerase-measured cellular senescence.