Outcome of Pre-Emptive Intravenous Antiemetics Palonosetron Versus Combined Ondansetron and Dexamethasone in Caesarean Sections Performed Under Spinal Anaesthesia – A Prospective, Randomized, Comparative Study

Abstract

Introduction: Patient pleasure is an important outcome of hospital treatment after anesthesia. PONV is a typical intraoperative side effect that can result in patient discontent and delayed discharge from the surgical institution.

Aims: A prospective, double-blind, randomized study to compare the preventive effects and synergistic efficacy of intravenous injection antiemetics that combined ondansetron, dexamethasone, and palonosetron to prevent nausea and vomiting during and after surgery in patients undergoing spinal anesthesia for a cesarean section.

Materials and methods: This study was a prospective, randomized, double-blind, comparative study. It was conducted from of 18 months, from February 2021 to July 2022, in the wards of Midnapore Medical College and Hospital, the post-anesthetic care unit (PACU), and the gynecology operation room complex. Total 100 patients were involved in this study.

Result: According to this study, during the intraoperative phase, 11 patients (22%) in Group OD and 4 patients (8%), in Group P, received rescue antiemetic. When rescue antiemetic was used intraoperatively, Group OD's value was significantly greater than Group P's (p Value = 0.049950).

Conclusion: Based on the findings and analyses of the current investigation, it may be deduced that, administration of pre-emptive intravenous 0.075mg palonosetron reduces the incidence of nausea and vomiting during surgery and consumption of antiemetics in female patients having an elective cesarean surgery under spinal anaesthesia compared to pre- emptive use of combination of 6mg ondansetron and 8mg dexamethasone.