Advanced Hybrid Nano-Particles Peptides for Targeted Treatment of Pulmonary Fibrosis

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Yallam Sailaja, Saritha Pendlikatla, Prasanthi Samathoti, Amit Kumar Nigam, Mahendra Singh Ashawat, Manoj Kumar Katual, Zankhana Pramodchandra Sheth, Pydiraju Kondrapu

Abstract

The development of advanced hybrid nano-particles peptides for targeted treatment of pulmonary fibrosis represents a significant advancement in the field of respiratory medicine. This abstract aims to provide a concise overview of the research and its implications. Pulmonary fibrosis is a chronic and progressive lung disease characterized by fibrosis, inflammation, and damage to the lung architecture. The etiology of pulmonary fibrosis, particularly idiopathic pulmonary fibrosis (IPF), remains largely unknown. Recent research has focused on the potential of nanoparticle-based drug delivery systems for the treatment of pulmonary fibrosis. Various types of nanomaterials, including lipid-polymer hybrid nanoparticles, have shown promising therapeutic effects in both in vitro and in vivo studies. These nanocarriers offer targeted delivery of peptides and drugs to the lungs, potentially improving the efficacy and reducing the systemic side effects of treatment. The review of recent advances in nanoparticle applications for respiratory disorders highlights the potential of nanomedicine in overcoming the limitations of conventional drugs and its promising applications in the treatment of pulmonary diseases. The emerging delivery approaches for targeted pulmonary fibrosis, including the development of various drug delivery systems, provide valuable insights into the ongoing efforts to address the unmet medical needs in the management of this challenging condition. This review underscores the potential of advanced hybrid nano-particles peptides as a targeted treatment modality for pulmonary fibrosis, offering new hope for improved therapeutic outcomes.

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