GATA 3 Expression in Invasive Breast Carcinoma.

Abstract

Introduction: Burden of   breast   cancer is increasing with  change  in  lifestyle, so are the treatment modalities changing. Immunohistochemistry positivity can help in planning the management of cancers, similarly GATA3 labelling. Its role in breast cancers is less explored. Hence the study was planned.

Objectives: This study aimed to know the GATA3 expression in invasive breast carcinoma and its correlation with modified bloom Richardson grading.

Methods: A cross-sectional study was conducted for one year in a tertiary care government hospital in a south Indian city. All invasive breast cancers during the study setting was included in the study. Timeframe sampling was adopted; and Histopathological typing, grading and immunohistochemistry of the tumor was done. Immunostaining was also graded as per the strength of positivity.

Results: One-third patients belong to the age group of 51-60 years. Also, one-third of the invasive breast cancers were of ductal type. Almost half the patients were of grade 2. 90% cancers expressed GATA3, of which 50% expressed strong positivity and 32.5% expressed moderate positivity.

Conclusions: Grade of breast cancer was significantly associated with GATA3 expression. Higher the grade of breast cancer, weaker was the GATA3 expression. GATA-3 is expressed by most invasive breast cancers and are strongly associated with histological grade 1 followed by grade 2.