Effectivness of Tranexamic Acid Mouthrinse on Extraction Socket in Patients Undergoing Anticoagulant and Anti Platelet Therapy

Abstract

Background: The utilization of tranexamic acid mouthrinse has garnered significant attention in dental literature, particularly in the context of extraction sockets among patients undergoing anticoagulant and antiplatelet therapy. As individuals with such medical regimens face heightened risks of postoperative bleeding, exploring the effectiveness of tranexamic acid in this specific scenario becomes crucial.

Aim and objective: To evaluate the efficacy of tranexamic acid mouthwash on extraction socket in patient undergoing anticoagulant and anti-platelet therapy

Material and method: The study included 100 consecutive patients on antiplatelet and anticoagulant therapy, with INR levels between 1.9 and 3.5 on surgery day, requiring dental extractions. Following extractions, participants were instructed to use a 10% tranexamic acid mouth rinse, 5 ml four times daily for 7 days, documenting bleeding instances requiring pressure control and recording mouth rinse usage.

Result: In this study of 100 patients (60 males, 40 females; mean age 57.1 years), the duration of antiplatelet and anticoagulant prophylaxis ranged from 2 weeks to 20 years. Most patients (59%) were smokers. Antibiotics were used preoperatively and perioperatively. Seventeen patients reported bleeding on day 1, controlled by tranexamic acid; nine required local measures in the dental surgery. Statistical analysis identified significant risk factors for post-extraction bleeding.

Conclusion: Research and statistical analysis suggest that employing tranexamic acid mouth rinses post-operatively in patients with therapeutic INR levels following dental extraction is a secure, uncomplicated, efficient, and well-received approach to minimize post-extraction bleeding.