Clinical Cases Anticoagulation Overdose with Concomitant Assumption of Vitamin K Antagonists and Asteraceae Family Green: A Review of the World’s Medicine

Abstract

Introduction: The world has had some studies on the effects of cruciferous vegetables on coagulation disorders as well as bleeding complications, but there are still many angles that need further research, especially the effects of green vegetables close to cruciferous vegetables such as Asteraceae family. The Asteraceae family is also a rarely mentioned food group.

Case series Description: Study on 3 cases of atrial fibrillation (AF), heart failure with dilated heart chambers, and artificial heart valve surgery who were using vitamin K antagonist anticoagulants (VKAs) drugs with green vegetables of the Asteraceae family that can cause anticoagulation overdose and was discovered when they were medical examination. Clinical cases found to have hemorrhagic bleeding in the background were acutely managed with timely resuscitation and returned the coagulation index to normal.

Conclusion: The case series of coagulation disorders who patients receiving anticoagulant therapy with vitamin K antagonists when using green vegetables of the Asteraceae family may be considered a risk factor for coagulation disorders and an increased risk of hemorrhagic complications.