Investigating the Impact of Plateletpheresis on Biochemical Bone Markers: A Focus on Osteocalcin, C-Telopeptide Type I Collagen, and Serum Calcium in Donors

Abstract

Introduction: : In plateletpheresis Citrate is used as an anticoagulant. The property of citrate is to chelate the calcium and prevent the coagulation cascade may causes hypocalcaemia in the plateletpheresis donor. Objectives: Aim and objects of this study is to investigate effect of citrate on bone markers in pre and post plateletpheresis donors. Methods: Comparative analytical Study was conducted among 90 healthy donors at Biochemistry Dept. and Blood Bank, Bharati Vidyapeeth (Deemed To Be ) University Medical College and Hospital .Sangli  Maharashtra .from November 2018 to December 2020.  Blood sample was taken from donors before and after 30 min. and measure the levels of serum calcium, osteocalcin, CTX and i-PTH  in pre and post donations.

Results: The statistical significance (p < 0.000) of the observed changes in serum calcium, osteocalcin, CTX, and i-PTH levels after plateletpheresis emphasizes the robustness of these alterations across all donors. Further research is essential to elucidate the underlying mechanisms and potential implications of these changes on bone health and overall physiological homeostasis.

Conclusions: The changes in serum calcium, osteocalcin, CTX, and i-PTH levels post-plateletpheresis suggest a dynamic interplay between the procedure and the body's regulatory mechanisms. Further research is needed to elucidate the specific mechanisms underlying these alterations and their potential implications for bone health and overall physiology.