Study On Surgical Treatment Of Intradural Extra medullary Spinal Cord Tumors

Abstract

In this study, we report the synthesis of novel Schiff bases and β-lactam derivatives derived from thiomorpholine and morpholine compounds, elucidating their antimicrobial, antioxidant, antituberculosis, anti-urease, and acetylcholinesterase inhibition properties. Our systematic investigation aimed at introducing innovative structures to the scientific literature, thereby contributing valuable insights to the field of medicinal chemistry.  The synthesized compounds were rigorously screened for their biological activities, revealing noteworthy efficacy in various domains. Compound 3b exhibited remarkable antituberculosis activity, while compounds 6a demonstrated potent Acetylcholinesterase Inhibition effects. Additionally, compound 3b displayed notable antioxidant capacity against standard drugs, underlining its potential therapeutic relevance. Moreover, compounds 3b, 6a, and 6b emerged as promising entities with excellent anti-urease activity against thiourea. Our study presents a significant advancement in the synthesis of structurally diverse compounds with morpholine and thiomorpholine moieties. The comprehensive screening of these compounds for diverse biological activities provides a nuanced understanding of their potential applications in medicinal chemistry. These findings contribute to the development of novel compounds with promising biological activities, fostering further exploration in drug discovery and development realms.