Grape Seed Chemical Composition and Its Activity on Different Leukemia Cell Lines: A Review

Abstract

Recent researches on natural chemicals as potential cancer drugs has been focused on grape seeds, a plant-derived extract with a complex chemical structure and health benefits. Grape seeds are rich in bioactive compounds that have potential health-promoting effects. The combination of polyphenols, flavonoids, and procyanidins in grape seeds results in a powerful collection of antioxidants. Polyphenols, particularly proanthocyanidins, have significant potential in cancer research. Flavonoid compounds, such as catechin and epicatechin, exhibit significant antioxidant activity and are considered promising candidates for both the prevention and treatment of cancer.

Leukemia, a blood cancer characterized by the uncontrolled proliferation of white blood cells, presents significant problems due to the limited availability of effective therapeutic interventions. Grape seed extracts have been investigated for their potential in combating various cancer cell lines, including leukemia. The study of grape seed extracts has revealed intricate mechanisms of action, such as apoptosis induction, which acts as a protective mechanism against cancer cell proliferation. The complex interaction between bioactive compounds found in grape seeds and specific molecular targets within JURKAT cells presents opportunities for the development of novel drugs for treating leukemia. This review gives insight the potential effects of grape seed components on cancer cell lines, specifically leukemia, focusing on K562, HL60, and JURKAT cell lines.