In-Vitro Evaluation of Antiulcer Activity of Selective and Functional Millet

Abstract

Introduction: Peptic ulcer disease (PUD) is a gastric condition which occurs because of an imbalance between defensive and harsh factors, like gastric mucus, secretion of bicarbonate, prostaglandins, and intrinsic resistance of mucosal cell components. There are several medication treatment options available for PUD, but their use is limited due to poor compliance and frequent side effects. Due to this reason, alternative for this treatment was religiously searched and continued and finally found natural phytochemical isolated from plants which possess less side effects, ease of accessibility and affordability and hence considered to be a great traditional medicines in the treatment of PUD

Objective: To design, develop and formulate functional millet formulation and evaluate physicochemical characterization, phytochemical screening and in-vitro study of the prepared powder product for the antiulcer activities.

Method: In present research study, sorghum, finger millet, pearl millet and sesame seeds were used. Millet formulation was used as the novel source of drugs for the antiulcer medications. Its in-vitro H+, K+-ATPase inhibition and Acid neutralizing capacity was analyzed on enzyme extract obtained from fresh goat stomach against standard drug omeprazole and Al(OH)3+Mg(OH)2 respectively

Result: At a concentration of 1000 μg/ml of millet sample and omeprazole found 56.75 % and 84.48 % of inhibition respectively. The millet sample at concentration 2000 mg/ ml was observed to neutralize acid as compared to standard.

Conclusion: From the results that the millet formulation represents a novel drug source for antiulcer treatments. Nevertheless, a comprehensive in-vivo study on the pharmacological assessment and Future research will be done to determine the underlying mechanism of action that accounts for its antiulcer efficaciousness.