Aqueous Extracts of Glycyrrhiza Glabra Linn and Diosmetin Effect on Ambulatory and Behavioral Functioning in Wistar Rats with Ethanol-Induced Cognitive Impairment.

Abstract

The aging process, exposure to various chemicals, radiation, and stressful situations can contribute to the degeneration of nerve cells in the brain, leading to cognitive decline. Alcohol-induced mild cognitive impairment (MCI) is a growing concern among middle-aged adults, affecting emotional response, memory, and learning processes. The hippocampal region, a crucial component of the limbic system, plays a primary role in memory and learning. Alcohol-induced MCI is associated with oxidative stress, cholinergic system damage, and inhibition of key receptors in various brain regions. Ethanol alters processes dependent on glutamatergic and dopaminergic inputs, resulting in cognitive impairment. Younger individuals may be more susceptible to ethanol's effects on motor and cognitive functions. This study explores the potential therapeutic benefits of natural products in mitigating ethanol-induced neurotoxicity, focusing on the aqueous extract of GGL (AqGg) and Diosmetin (Dm). AqGg, a herbal extract frequently used in the Indian medical system, is known for its memory and learning-enhancing properties. Diosmetin, a well-known antioxidant molecule, has shown promise in improving working memory and spatial learning. The research aims to investigate the antioxidant properties of AqGg and Dm in protecting against cognitive and ambulatory impairment induced by ethanol. The study includes an assessment of the impact on declarative and episodic memory, considering corticostriatal and limbic system-hippocampus connections