Formulation, Development and Evaluation of Aloe Vera Contain Polyherbal Emulgel for Topical Drug Delivery System

Abstract

The administration of medications to any part of the body through the skin, the vaginal channel, the ocular route, or the rectal route is referred to as topical drug delivery. It is possible for drugs to be administered either locally or systemically. It is possible to design topical formulations with varied physicochemical qualities, such as those having a solid, semisolid, or liquid consistency. The preparation of a drug emulsion and its incorporation into an emulgel are the two steps involved in the production of the topical system. Emulgel is a formulation that is both thermodynamically stable and has low interfacial tension. It has many desirable properties, such as high thermodynamic stability and improved permeability, and is made by combining a surfactant with a co-surfactant. Emulgel has a continuous and dual-controlled release pattern. With emulgel, the medicine is more bioavailable and the patient is more likely to take it as prescribed. To find out how the formulation turns out, we put it through its paces in terms of viscosity, particle size, zeta potential, medicine content, stability, and skin irritant rating, among other things.