Development of Topical Polyherbal Emulgel and Evaluation of Its Antimicrobial and Antiinflammatory Activities

Abstract

In the current investigation, three medicinal plants Aloe barbadensis miller, Syzygiumaromaticum, and Eucalyptus globules that have a substantial ability to reduce inflammation were chosen to be formulated into a polyherbal Emulgel. Polyherbal Emulgel formulations were tested for their pH, appearance and homogeneity, viscosity, spreadability, and skin irritation tests. The Aloe barbadensis miller, Syzygiumaromaticum, and Eucalyptus globules oil used to make the polyherbal Emulgel were the ingredients utilized to create the new formulations. To test the compound's anti-inflammatory capabilities, it was administered to rats with carrageenan or formalin to cause paw edema. It was discovered that both individual and polyherbal gels of Aloe barbadensis miller, Syzygiumaromaticum, and Eucalyptus globules have an anti-inflammatory effect in both acute and chronic settings. When compared to separate gels, Polyherbal Emulgel demonstrated a synergistic effect, which indicates that it may be beneficial for the treatment of local inflammation.