Comparative Analysis of C-Reactive Protein Levels: Evaluating the Impact of 0.12% And 0.2% Chlorhexidine Mouthrinses in Non-Surgical Periodontal Therapy

Abstract

Background: C-reactive protein (CRP) serves as an inflammation indicator naturally found in plasma, with levels that can elevate in response to inflammatory activities. This increase is linked to an elevated risk of cardiovascular events, such as acute myocardial infarction. The immune-inflammatory response triggered by periodontal disease plays a role in elucidating its connection with cardiovascular issues.

Methods: For the proposed study, a total of thirty participants were selected and randomly assigned to three groups: the Control group, Test group A, and Test group B. In Test group A, consisting of 10 patients, plaque control was implemented using chlorhexidine 0.12% mouthrinse as a supplementary measure after one month of non-surgical periodontal therapy (NSPT). Follow-up assessments were conducted at baseline, 1 month, and 2 months. Similarly, Test group B, also comprising 10 patients, underwent plaque control with chlorhexidine 0.2% mouthrinse following one month of NSPT, with evaluations conducted at the same intervals. This design allows for a comparative analysis of the effectiveness of different chlorhexidine concentrations as adjuncts to NSPT in managing periodontal health.

Results: The study assessed mean percentage reductions in Plaque Index (PI) across three groups. In Group A (n=10), reductions were 12.86 ± 1.10 (0-1 month), 6.75 ± 0.97 (1-2 months), and 20.64 ± 2.01 (0-2 months). Group B (n=10) showed reductions of 12.41 ± 1.10, 7.27 ± 1.40, and 20.94 ± 2.38 for the same intervals. The Control Group's (n=10) reductions were 13.08 ± 1.70, 6.40 ± 0.88, and 21.10 ± 2.22. These results highlight intervention variances, providing insights into Plaque Index changes over the study periods.

Conclusion: Significantly greater improvement in clinical parameters was observed with the use of 0.12% and 0.2% chlorhexidine mouthrinses compared to non-surgical periodontal therapy alone.