Formulation and Evaluation of Polyherbal-Based Antiaging Capsules Containing Tinospora Cordifolia, Ocimum Basilicum, and Centella Asiatica

Abstract

This research article explores the formulation and evaluation of polyherbal-based antiaging capsules containing Tinospora cordifolia, Ocimum basilicum, and Centella asiatica. The study encompasses meticulous extraction processes, innovative formulation techniques, and comprehensive evaluations. The leaves of the selected plants underwent a detailed extraction process using advanced techniques, resulting in high-quality plant material. The formulation of capsules involved a systematic approach, employing a Design of Experiment (DOE) methodology. Eight unique batches of capsules were prepared and evaluated, with the optimized formulation (C5) demonstrating excellent in vitro drug release characteristics within 120 minutes.

Chromatographic studies using HPTLC fingerprinting confirmed the presence and stability of active constituents (quercetin, berberine, madecassoside) within the formulated capsules. The RF values and linearity observed at different wavelengths provided additional evidence of the robustness and integrity of the formulated product. The results of the in vitro drug dissolution study revealed a controlled and sustained release pattern for the optimized formulation, demonstrating 76.14% drug release in phosphate buffer pH 6.8 and 62.08% in 0.1 N HCL within 120 minutes.

In conclusion, this research contributes valuable insights to the field of herbal pharmaceuticals, offering a promising avenue for the development of effective antiaging formulations. The combination of innovative formulation strategies and comprehensive evaluations positions these capsules as a noteworthy advancement in the pursuit of herbal-based solutions for antiaging interventions.