Physiochemical Analysis, Antipyretic and Anti-Inflammatory Potential of Kanakasava

Abstract

ABSTRACT:

Kanakasav is recommended in Ayurveda to cure inflammatory disorders so in present study physiochemical properties along with antipyretic and anti-inflammatory potential of Kanakasava was studied. Kanakasava was prepared according to Ayurvedic formulary. Kanakasava was administered orally to wistar albino rats to study acute toxicity. The antipyretic activity was evaluated by using Brewer’s yeast-induced pyrexia model in rats, and anti-inflammatory activity was evaluated in the carrageenan-induced paw edema model in wistar albino rats.The findings showed that Kanakasav physiochemical parameters was in accordance with Ayurvedic Pharmacopoeia monograph and it contains active secondary metabolites such as alkaloids,flavonoids,Phenolics etc. Quantitative HPTLC showed that Kanakasav contain significant quantity of Quercetin.

Moreover,the results of an acute toxicity test showed no mortality in dose up to 10ml/kg. Kanakasav has possess remarkable anti-inflammatory and antipyretic potential. So, in future it may be use as safer alternative to synthetic drugs.