Antagonistic Activities of Pharmaceutical Probiotics and Prebiotic from Fermented Food Products against Selective Human Urinary Pathogen

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Avra Pratim Chowdhury, Bhriganka Bharadwaj, Sangita Boro, Dhritismita Deka, Ayan Paul, Smeet Jyoti Kalita, Moni P Bhuyan

Abstract

Introduction: Pharmaceutical probiotics are widely used for the treatment of gut-associated infections. Probiotics are prescribed along with antibiotics and in many cases instead of antibiotics. The beneficial effects of using probiotics have already been established through various research studies. But a pharmaceutical processed combination of different species of gut acting normal flora as a probiotic supplement and its toxin may result from pathogenesis in gut health.


Objective: Previous research explained low-grade side effects resulting from excessive use of probiotics. The present study was carried out to observe the effect of different doses of probiotics and their antagonistic reflex against specifically identified pathogen Klebsiella sp.


Method: The basic concept was triggered for isolations and condign of purified probiotics from food samples to decorate the proportional impact by an indicator pathogen determined from human urine samples. The outfit progress and results were modified by in-vitro analysis for a new medicinal approach against urinary tract pathogens. The mode of action was subjected to assemble their consecutive analysis.


Result: Implementation of additional content of the pharmaceutical product was used apart from the probiotic dosages. The expected target dose and assessments on the effects were clarified after the implementation of screened probiotics along with antibiotics.


Conclusion: The outcome inferred that, if any patient took probiotic along with long courses of antibiotics, it becomes dead in downstream blood. The secrets are the toxin triggered by accessed antibiotic doses, and the killer motif of probiotic acts against itself to prohibit the medicinal action in the gut.

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