Evaluation of Antihyperlipidemic Activity of Ethanolic Extract of Lathyrus Sativus Linn. on Rats.

Abstract

Introduction Hyperlipidemia is a major contributor to atherosclerosis and its accompanying conditions, including coronary heart disease, ischemic cerebrovascular disease, and peripheral vascular disease. The majority of morbidity and mortality among middle-aged people's mortality and morbidity and older adults still results from atherosclerosis-related events, although their incidence has decreased in the United States. As a result of the obesity epidemic and the ageing of the American population, both the incidence and the absolute number of annual events will rise over the coming ten years..

Objectives Evaluation of Antihyperlipidemic Activity of Ethanolic Extract of Lathyrus sativus Linn. on rats.

      Methods: Screening of antihyperlipidemic was done by using Lathyrus sativus Linn.. Leaves part extracts used for antihyperlipidemic activity leaves (200mg/kg). Hyperlipidemia was administered in experimental animals using triton X-100 administered intraperitoneally at a dose of (100 mg/kg). In order to collect blood for triton-induced hemolysis, retroorbital punctures were performed every 24 hours. hyperlipidemia and 28 days for high fat diet induced hyperlipidemia. Antihyperlipidemic activity of Lathyrus sativus Linn. plant extracts were evaluated by estimation of lipid profiles and standard drug Atorvastatin for 28 days. The biochemical parameters such as The levels of Total Cholesterol, Triglycerides, Very Low Density Lipoprotein (VLDL), High Density Lipoprotein (HDL), and Low Density Lipoprotein (LDL) are assessed.

Results: Estimation of lipid profile shows that Lathyrus sativus Linn. leaves extract (200mg/kg), Lathyrus sativus Linn. leaves extract (200mg/kg) shows the less significant antihyperlipidemic activity. It decreases TC, TG, LDL, VLDL and increases HDL levels. Lathyrus sativus Linn. leaves extract 200 mg/kg shows significant antihyperlipidemic activity as standard drug Atorvastatin.

Conclusions: This finding tends to reveal that the  hyperlipidemic effects of Lathyrus sativus Linn. are similar to the effect of standard drug Atorvastatin. This plant can get in consideration for the searching new drug to treat hyperlipidemic from plant.